To the Editor.—
Certain constitutional diseases associated with aneuploidy and other cytogenetic defects carry an increased risk of leukemia.1 Klinefelter syndrome may predispose to lymphoma, leukemia, and breast cancer, while the XYY syndrome may be associated with leukemia. Constitutional aneuploidy was found in five of 43 phenotypically normal individ uals with acute leukemia.2,3 By staining the nuclei of buccal mucosal cells, it is possible to rapidly screen large numbers of patients for numerical abnormalities of the X4 and Y5 chromosomes without time-consuming cytogenetic analyses. We sought to determine the presence of numerical changes in the sex chromosomes of men with leukemia and lymphoma and also to ascertain whether treatment with cytotoxic agents alters the incidence or expression of the sex chromatin in buccal mucosal cells.The men were attending an outpatient clinic for the treatment of leukemia and lymphoma. Controls were men with nonmalignant blood disorders
Spiers ASD. Sex Chromatin in Men With Leukemia, Lymphoma, and Hypertension. JAMA. 1977;237(10):958. doi:10.1001/jama.1977.03270370030004
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