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March 7, 1977

Estrogens and Endometrial Cancer

Author Affiliations

University of Louisville School of Medicine Louisville

JAMA. 1977;237(10):958. doi:10.1001/jama.1977.03270370030005

To the Editor.—  The SPECIAL COMMUNICATION entitled "Estrogens and Menopause" by Carol M. Proudfit, PhD (236:939, 1976), while timely, contains data that, if incorrect, could well have misled the author and resulted in erroneous conclusions in the final paragraph. The data that I question were attributed to Austin (reference 5). Since I am not privy to Austin's communication, I cannot tell if the difficulty lies in a typographical error, a misinterpretation, or a unique endometrial cancer problem in California.An incidence of invasive carcinoma of the uterus of 180/100,000 population as reported would not seem likely, even if cancer of the cervix were included. Although it is not entirely clear, I presume the author is referring to only carcinoma of the corpus. Even an incidence rate of 100/100,000 population, which is the rate from which endometrial cancer allegedly increased (1969 vs 1974), would appear to be from four to five times