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March 7, 1977

Estrogens and Endometrial Cancer-Reply

Author Affiliations

Resource for Cancer Epidemiology and California Tumor Registry Berkeley

JAMA. 1977;237(10):959. doi:10.1001/jama.1977.03270370030007

In Reply.—  The issues raised by Christopherson focus attention on the use of two types of incidence rates: ageadjusted and age-specific. His observation regarding the California rates would be essentially correct if the population of interest were the total female population. Proudfit's article, however, is directed specifically to the assessment of measures of risk of endometrial cancer among postmenopausal women. Accordingly, she accurately cited data from the California Tumor Registry for white women, aged 50 to 74 years.The Table illustrates the effect of using (age-adjusted) rates for total white women and of using (age-specific) rates for only the postmenopausal age group cited by Proudfit. While the annual age-adjusted rates are more comparable to those cited by Christopherson, the apparent increase in incidence over the period of observation is substantially diminished. By contrast, the proportional increase in the older age group is much greater, reflecting the fact that a highly