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March 7, 1977

Reiter Disease in Siblings

Author Affiliations

Fullerton, Calif

JAMA. 1977;237(10):960. doi:10.1001/jama.1977.03270370032010

To the Editor.—  With the high incidence of HLA-B27 positivity, which has recently been recognized in Reiter disease,1 it is unusual that the disease is not more prevalent in close family members. There have been very few reports of Reiter disease in more than one member of a family.2,3 I wish to report two brothers with classic Reiter disease who were also found to be positive for the HLA-B27 histocompatibility antigen.

Report of Cases.—Case 1.—  In a 19-year-old white man, urethritis, conjunctivitis, acute arthritis of the right ankle and the left knee, balanitis circinata, and painless shallow ulcerations of the mucous membranes of the mouth developed. Cultures of urethral and synovial fluid were negative. The sedimentation rate was 46 mm/hr and rheumatoid arthritis latex test was nonreactive. X-ray films of the knees, ankles, lumbosacral spine, and sacroiliac joints were normal. The patient failed to respond to