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November 19, 1973

Bladder Carcinoma

JAMA. 1973;226(8):1012. doi:10.1001/jama.1973.03230080148041

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To the Editor.—  The July 30 issue of The Journal (225:528, 1973) carried a letter from Alvaro Morales regarding the development of diffuse urothelial malignancy in a patient exposed to shoe polish. Without disputing the implication of an occupational causation, as there was insufficient information provided to support or refute such a contention, I should like to correct the statement that... "aniline dyestuffs... have been the classical industrial bladder carcinogens." Substances associated with aniline dye manufacture, such as benzidine and beta-naphthalamine, have been the classical industrial bladder carcinogens. Aniline dyestuffs are not known to be bladder carcinogens.