Prazosin hydrochloride, a new antihypertensive agent, is said to be of mild-to-moderate potency when used as a sole agent in mild-to-moderate hypertension and when used in conjunction with other agents in severe hypertension. In our study of 14 patients comparing hydrochlorothiazide with prazosin, the antihypertensive effect of prazosin was less than that of hydrochlorothiazide.
The greatest application of prazosin may be in conjunction with thiazide diuretics and β-adrenergic blocking agents as the second or third drug.
(JAMA 237:989-991, 1977)
Schirger A, Sheps SG. Prazosin—new Hypertensive Agent: A Double-Blind Crossover Study in the Treatment of Hypertension. JAMA. 1977;237(10):989–991. doi:10.1001/jama.1977.03270370061024
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