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March 7, 1977

Burkitt Lymphoma in a Patient With Neurofibromatosis and Pheochromocytoma

JAMA. 1977;237(10):993-994. doi:10.1001/jama.1977.03270370065026

MULTIPLICITY of tumors is being recognized with increasing frequency. The association of pheochromocytoma with Recklinghausen neurofibromatosis is a well-known but infrequent phenomenon. To the best of our knowledge, neither has been reported as occurring together with Burkitt lymphoma. We report the unusual occurrence of Burkitt lymphoma, pheochromocytoma, and Recklinghausen neurofibromatosis in a single person and comment on possible interrelationships.

Report of a Case  In July 1973, a 20-year-old woman underwent curetting of a mass growing at the site of a prior dental extraction. Histologic examination suggested an anaplastic malignant process. In the course of her evaluation, multiple cafe-au-lait spots were noted on the trunk and extremities along with numerous 0.5-cm, spongy, subcutaneous nodules on the abdomen and lower back. Findings from a bone marrow aspiration and biopsy were compatible with iron deficiency anemia. Over the next two months, an expanding mass, which was lytic on roentgenograms, developed in the posterior