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March 7, 1977

Clinical and Biochemical Aspects of Lactic Acidosis

JAMA. 1977;237(10):1010. doi:10.1001/jama.1977.03270370082037

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This volume is a very well-referenced summation of lactic acidosis, covering the biochemistry and physiology in much detail, but intelligible to clinicians having some current familiarity with metabolism. In fact, even the less academically oriented practitioner could, with a little extra time, derive a clear-cut understanding of the interrelationships of such things as redox potential, state of adenine phosphorylation, and the complicated pathways of pyruvate metabolism, and could relate these to lactate levels in the patient. Important also is the list of more than 500 references covering both pathophysiology and therapy, with welldrawn roadmaps of metabolic pathways and selected patient histories serving as typical examples of the various types and therapies of lactic acidosis. The possible contributory effects of drugs, especially the biguanides, are discussed in detail.

Since each clinical form of lactic acidosis is described in toto, there is much repetition between chapters, but the advantage of this is