A patient with Felty syndrome underwent splenectomy because of persistent high fever, leg ulcer, and granulocytopenia. Subsequently, his rheumatoid synovitis went into prolonged remission. In addition, the leg ulcer healed; his WBC count, hemoglobin level, temperature, ESR, and weight returned to normal; the rheumatoid factor titer dropped substantially; and the antinuclear antibodies disappeared. These changes have persisted to the present time, more than 5 1/2 years after surgery.
(JAMA 237:1116-1118, 1977)
Khan MA, Kushner I. Improvement of Rheumatoid Arthritis Following Splenectomy for Felty Syndrome. JAMA. 1977;237(11):1116–1118. doi:10.1001/jama.1977.03270380060021
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