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March 14, 1977

Hyperthyroidism Followed by Scleroderma

Author Affiliations

From the Departments of Endocrinology (Dr Ward), Pathology (Dr Mendeloff), and Nuclear Medicine (Dr Coberly), Veterans Administration Hospital, Decatur; and the Department of Medicine (Dr Ward), Pathology (Dr Mendeloff), and Radiology (Dr Coberly), Emory University School of Medicine, Decatur, Ga.

JAMA. 1977;237(11):1123. doi:10.1001/jama.1977.03270380067024

A RECENT report of scleroderma and hyperthyroidism1 suggested that scleroderma had not been reported in direct association with hyperthyroidism. We describe a patient in whom scleroderma was diagnosed at the time of radioactive iodine therapy for hyperthyroidism. The subsequent course of his scleroderma has been one of continued improvement.

Report of a Case  A 45-year-old man was transferred on March 17, 1964, from another Veterans Administration Hospital for treatment of hyperthyroidism. Initially, he had complained of a 13.5-kg weight loss, diarrhea, and fluttering of the heart. His protein-bound iodine (PBI) level was 10.1μg/100 ml (normal, 4μg to 8μg/100 ml), and he had been taking methimazole. To confirm the diagnosis, the methimazole regimen was discontinued, whereupon the PBI value rose to 15μg/100 ml. A 24-hour radioactive iodine uptake was 61% (normal, 15% to 35%). On April 29, 1964, he received 7.98 mCi131I.He was next seen in June 1964,