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December 3, 1973

Psychopathology and Psychopharmacology

JAMA. 1973;226(10):1238. doi:10.1001/jama.1973.03230100056030

In 1867, Maudsley's Physiology and Pathology of the Mind stressed the need to search for a "material basis for mental activity." More than one hundred years later, despite burgeoning neuropharmacological research efforts, the "material basis" that Maudsley spoke of still has not been delineated. Thus, it is not surprising that members of the American Psychopathological Association chose to pause and reflect during their 62nd Annual Meeting and consider "psychopathology and psychopharmacology" as their main topic of discussion. This volume contains papers presented at that meeting.

In the long-standing search for an etiological agent of schizophrenia, investigators have passed through various stages. Infectious agents were initially sought. Later, "auto-intoxicants," genetically induced psychotoxins, and autoimmune responses occupied researchers' attentions. In this era of hallucinogen synthesis, it is not surprising that "drug models of schizophrenia" occupy the entire first part of the book. Eight papers deal with drug-induced behavioral changes of LSD, anticholinergics,