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To the Editor.—
Amantadine hydrochloride (Symmetrel) has two separate and apparently unrelated pharmacologic actions: It is most commonly used to control the tremor of Parkinson disease, and it has an antiviral action in the prevention of type A influenza. Blurring of vision has been reported as an infrequent complication of drug use. The mechanism causing this problem is unknown.
Report of a Case.—
A 67-year-old man was first seen in 1973 for a routine eye examination. Apart from a mild astigmatic refractive error and the normal presbyopia of his age, the findings were completely within normal limits. He was seen again in August 1975 for a superficial corneal abrasion of the right eye, which cleared spontaneously without sequelae. In September 1975, his vision was fully correctable to 20/20 in each eye, with no evidence of incipient cataracts, glaucoma, macular degeneration of the retina, or optic nerve disease.In November 1976,
PEARLMAN JT, Kadish AH, Ramseyer JC. Vision Loss Associated With Amantadine Hydrochloride Use. JAMA. 1977;237(12):1200. doi:10.1001/jama.1977.03270390016009
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