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March 21, 1977

Allergy to Mace

JAMA. 1977;237(12):1201. doi:10.1001/jama.1977.03270390017014

To the Editor.—  Dr Frazier's article (236:2526, 1976) is not the second reported instance of allergic contact dermatitis to chemical mace. In 1969, we reported several cases of allergic contact dermatitis to chloroacetophenone, the active ingredient in chemical mace.1 Furthermore, we evaluated the sensitizing potential of this compound and studied cross-reactivities to related chemical compounds. We agree with Dr Frasier's conclusions that physicians should be aware of this undesirable complication which may be associated with the use of chemical mace.