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February 9, 1970

Evaluation of Three Rubella Vaccines in Adult Women

Author Affiliations

From the Section of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine (Drs. Halstead and Diwan) and the University of Hawaii Student Health Center (Dr. Char), Honolulu.

JAMA. 1970;211(6):991-995. doi:10.1001/jama.1970.03170060055011

A currently licensed rubella vaccine, HPV 77, produces arthralgia at high frequency in adult women. Thirty-nine susceptible adult women, ages 18 to 37 years, were inoculated with Cendehill, Benoit B, and Benoit C rubella vaccine strains and evaluated clinically and serologically. Benoit B produced rubellalike disease including polyarthralgia in five of seven women which, in one case, was of five months' duration. The postvaccination course of Benoit C vaccine was benign in all 11 subjects; only two of 28 Cendehill vaccinees had mild, transient arthralgia. Postvaccination hemagglutination-inhibition antibody to levels greater than 1:10 developed in all susceptible subjects. Benoit B vaccinees had the highest titers, Cendehill, intermediate values, while Benoit C titers were rather low. Cendehill and perhaps Benoit C strains appear to be immunogenic and clinically acceptable in adult women.