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March 28, 1977

Virus-Induced Hyperlipoproteinemias

Author Affiliations

Health Central Institute and Life Sciences Foundation Minneapolis

JAMA. 1977;237(13):1311. doi:10.1001/jama.1977.03270400015003

To the Editor.—  The studies of Nichols et al (236:1948, 1976) have shed further light on the dietary aspect of hyperlipidemia problem.We would like to call the attention of researchers and practicing physicians to a curious, newly recognized phenomenon in experimental animals: virus-induced hyperlipoproteinemias.1,2 Our studies involving the use of human malignant melanoma isolate virus, SV-40 type, showed that this virus could produce severe hyperlipidemia (type IV) in hamsters.1 Other investigators2 observed hyperlipemia induction by the arborvirus group in chicken embryos.We feel that these observations might have some importance in understanding the mechanism of acute hyperlipemia phenomenon leading to thromboembolic syndrome in man. One of us (M.G.) has repeatedly observed transient type IV hyperlipoproteinemias during viral upper respiratory tract infections, particularly in patients with coronary artery disease. Epidemiological studies have repeatedly shown that the death rates were 50% higher from coronary artery disease during the winter