This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor.—
Our most recent experience with the prothrombin concentrate Konyne in factor VIII inhibitor patients has shown considerable variation in potency of various lots with respect to coagulant content as well as clinical effectiveness. Another investigator has made a similar observation (Charles Abildgaard, personal communication). We would suggest the manufacturer be contacted regarding potency of their product before employing it to control bleeding in inhibitor patients.As noted in our article (236:2061, 1976), the other commercially available prothrombin concentrate, Proplex, has undergone a change in processing and does not appear to be effective. The investigational product Auto IX continues to provide a good therapeutic response in this condition.
Penner JA, Kelly PE. Prothrombin Complex Concentrates for Inhibitor Patients. JAMA. 1977;237(13):1311–1312. doi:10.1001/jama.1977.03270400015004
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: