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March 28, 1977

Fluorouracil for Skin Blemishes and Lines

JAMA. 1977;237(13):1312. doi:10.1001/jama.1977.03270400016006

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To the Editor.—  The author of a book for laymen (that has had a wide sale) advocates the use of fluorouracil for the peeling of the skin for blemishes and lines. This type of treatment has appeared in many popular lay magazines and may cause some physicians to use this method.I am enclosing two after-slides of a patient who consulted me for treatment after fluorouracil had been used on her skin with very damaging results. The patient suffered severe pain, edema, and a dermatitis of the erythema livedo reticularis type. Fortunately, I was able to clear this damaging condition with topical applications of aluminum acetate (Burow's) solution, hydrocortisonetype cream applied topically, and prednisone, 5 mg twice daily for four weeks.