An efficient protocol for the evaluation of hypertensive cases included renal arteriography, suppression and stimulation of the renin-aldosterone system, and, when indicated, renal venous renin measurements. It permitted identification of 38 patients with renal artery stenosis, 28 with primary aldosteronism, and 51 with high renin, 92 with normal renin, and 27 with low renin essential hypertension.
(JAMA 237:1331-1335, 1977)
Grim CE, Weinberger MH, Higgins JT, Kramer NJ. Diagnosis of Secondary Forms of Hypertension: A Comprehensive Protocol. JAMA. 1977;237(13):1331–1335. doi:10.1001/jama.1977.03270400035014
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