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February 23, 1970

Experimental Pneumoconiosis

Author Affiliations

Jackson Memorial Hospital Miami, Fla

JAMA. 1970;211(8):1380-1381. doi:10.1001/jama.1970.03170080068031

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This book reviews experimental pneumoconiosis from the 1920's to the early 1960's. An introductory chapter recounts the ancients' awareness of the dangers of dust to miners. A description of the minerals causing pneumoconiosis and of the related industries is valuable. Experimental methods for studying silicosis are described minutely. Variations in species reactions are noted; perfect silicotic nodules are found in the white rat, diffuse fibrosis in rabbits. Species vary in effectiveness of nasal filtration of dust and metabolic rate and phagocytic activity in the experimental animal should match that of man. The pathology of silicosis is superficially discussed but there is an excellent account of experimental silicosis. Theories of pathogenesis of various pneumoconioses are reviewed, as are the many suggested treatments. Insufficient emphasis is made of the nonspecificity of the asbestos body. The few cases where pure carbon could have been fibrogenic are reviewed. Many would dispute the dogma that