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January 7, 1974

Reducing Side Effects in Ketamine Anesthesia

Author Affiliations

Loyola University Stritch School of Medicine Maywood, Ill
University of Illinois Hospital Chicago

JAMA. 1974;227(1):78. doi:10.1001/jama.1974.03230140048024

To the Editor.—  The report on the work of Dr. Albin and associates in the MEDICAL NEWS section (226:414, 1973) suggested that tetrahydroaminacrine (THA) can lessen the recovery time and reduce the severity of the emergence reactions in dogs.Certain other features of the pharmacology of THA need emphasis, especially when orientated to anesthesia.The stimulating or the arousal effect of THA is nonspecific and is known to shorten the sleeping time after barbiturates, morphine, or general anesthesia. Its central nervous stimulating action was described by Shaw and Bentley (1952).1 Stone et al combined THA with morphine to reduce the respiratory depression in the treatment of intractable pain.2 They noticed that the patients were more awake and alert. They called it a partial antagonist since it did not nullify the pain relief entirely, as compared with other narcotic antagonists such as naloxone. Studies to determine whether the antipsychotic