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April 11, 1977

Standard Nomenclature for Primary Hepatic Tumors

Author Affiliations

Department and Registry of Hepatic Pathology Armed Forces Institute of Pathology Washington, DC

JAMA. 1977;237(15):1559-1560. doi:10.1001/jama.1977.03270420027008

To the Editor.—  I wholeheartedly agree with Dr Mays (236:1469, 1976) that there is a great deal of confusion regarding the terminology of benign tumors of the liver. This state of affairs, however, is the result of lack of experience with these tumors, rather than the absence of clearly defined morphologic criteria. In reference to those tumors that have been discovered in women receiving oral contraceptives, the confusion has been compounded by histologic reinterpretations (and sometimes reinterpretations of the reinterpretations) of the published cases. The two tumors that have been frequently confused, viz, hepatocellular adenoma and focal nodular hyperplasia, have been well characterized and clearly distinguished morphologically for many years.1-3 Also, an internationally accepted classification of hepatic tumors has been completed by the World Health Organization. Although the illustrated monograph has not yet been published, that classification has been incorporated into the recently published Standardized Nomenclature, Diagnostic Criteria and