The incidence of liver abscess discovered at autopsy at the Mallory Institute of Pathology has remained fairly constant over the past 70 years (0.57%). The causes, however, are changing. In a review of cases over the period 1959 through 1968, it was discovered that (1) the incidence of liver abscess secondary to acute appendicitis decreased, but liver abscess secondary to biliary obstruction from cholelithiasis or carcinoma increased, and (2) the percentage of abscesses associated with Gramnegative bacteria has increased steadily since the introduction of antibiotics.
de la Maza LM, Naeim F, Berman LD. The Changing Etiology of Liver Abscess: Further Observations. JAMA. 1974;227(2):161–163. doi:10.1001/jama.1974.03230150013003
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