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March 2, 1970

Skin Pigmentation in Wilson's Disease

Author Affiliations

From the Clinical Investigation Department, US Naval Medical Research Unit No. 2, Taipei, Taiwan.

JAMA. 1970;211(9):1542-1543. doi:10.1001/jama.1970.03170090058016

Twelve of 20 patients (60%) with Wilson's disease (hepatolenticular degeneration) were noted to have hyperpigmentation on the anterior aspect of the lower part of the legs. Histologically, this was found to be caused by increased melanin deposition. Copper and iron content in skin biopsy specimens was not different from that in controls.