THE ASSOCIATION of systemic amyloidosis with monoclonal-component or M-component diseases such as multiple myeloma, Waldenström macroglobulinemia, lymphomas, and leukemia is well known. The purpose of this communication is to present a case of aleukemic chronic lymphocytic leukemia with an IgM paraprotein M-component associated with primary systemic amyloidosis in which IgM was found in the skin lesions on immunofluorescent staining.
Report of a Case
A 52-year-old man came to our clinic with a five-month history of an asymptomatic generalized eruption of waxy papules. The eruption was preceded by two months of a gradual progression of numbness and burning in all extremities and a weakness in both hands.On physical examination, numerous smooth, skin-colored, translucent papules (2 to 4 mm), several with a hemorrhagic component, were noted on the elbows, knees, calves, shins, wrists, buttocks, and ventral aspect of the upper extremities (Fig 1). There were two areas of linear purpura on
Garcia RL, Backe JT. IgM in Skin Lesions of Systemic Amyloidosis. JAMA. 1977;237(15):1598–1599. doi:10.1001/jama.1977.03270420066020
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