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January 14, 1974

Handbook and Atlas of Gastrointestinal Exfoliative Cytology

Author Affiliations

Lankenau Hospital Philadelphia

JAMA. 1974;227(2):209. doi:10.1001/jama.1974.03230150057038

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This atlas on gastrointestinal cytology has been long overdue. During the past two decades the group from the University of Chicago has done pioneer work in this field. This book describes methods of cell collection and analysis of findings in lesions of the esophagus, stomach, duodenal region, and colon.

Statistics from old studies have been reviewed; in some instances current results are less satisfactory than earlier. For example, of 334 patients with adenocarcinoma of the stomach, only 259 (77.5%) had positive cytologic specimens; whereas in 1965, Annals of Internal Medicine, 220 (86%) of 257 had positive cytologic specimens.

Recent developments of fiberoptic endoscopy are discussed. The advantages are several—the cytologic specimen is taken at the same time as the endoscopy, rather than separately; collection time is markedly shortened; and the smears have large numbers of well-preserved pathologic cells. Interestingly, of 50 patients with malignant neoplasms, direct brushing resulted in positive,