. A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy. The edema disappeared with discontinuation of the drug regimen and did not reappear during a subsequent six-month observation period. It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.
(JAMA 237:1716-1717, 1977)
Schooley RT, Wagley PF, Lietman PS. Edema Associated With Ibuprofen Therapy. JAMA. 1977;237(16):1716–1717. doi:10.1001/jama.1977.03270430058021
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