[Skip to Content]
[Skip to Content Landing]
April 18, 1977

Edema Associated With Ibuprofen Therapy

Author Affiliations

From the Departments of Medicine (Drs Schooley and Wagley) and Pharmacology and Experimental Therapeutics (Dr Lietman), The Johns Hopkins University of Medicine, Baltimore.

JAMA. 1977;237(16):1716-1717. doi:10.1001/jama.1977.03270430058021

. A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy. The edema disappeared with discontinuation of the drug regimen and did not reappear during a subsequent six-month observation period. It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.

(JAMA 237:1716-1717, 1977)