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April 18, 1977

The Immunology of Malignant Disease

JAMA. 1977;237(16):1730. doi:10.1001/jama.1977.03270430072029

This book is intended for clinicians concerned with the management of malignant disease. The first edition was published in 1970, and extensive revisions and additions have been made in the second edition. The volume tries to include sufficient basic information to provide an adequate background for understanding the clinical approaches.

The initial chapter, "Normal Immune Response in Man and Its Reaction to Malignant Disease," describes specific immune responses of adaptive immunity and various forms of immunologic reactions involving suppression of responses. Assays for measuring adaptive immunity in cancer patients are considered, while features of host defense and human malignant neoplasms are discussed in general terms. The chapter on "Immunology of Tumors in Experimental Animals" reviews the antigens found in virus-induced and chemically induced tumors, as well as embryonal antigens of tumors. Immune reactions to tumors and experimental approaches to immunotherapy are discussed.

The chapter on "Immune Deficiency States Associated With