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January 21, 1974

Pathophysiology of Gestation, vol 3; Fetal and Neonatal Disorders

Author Affiliations

Albuquerque, NM

JAMA. 1974;227(3):331-332. doi:10.1001/jama.1974.03230160059036

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In early postnatal life, the physiological functions of infants undergo marked transitional changes that serve to adapt every system of the body to the external environment. When these changes are judged by either fetal or adult standards, they may often appear pathological. Yet, when analyzed in view of recent knowledge, they appear mere physiological adjustments to extrauterine life. The present volume of this series includes discussions of several important systems in the newborn period— circulation, respiration, bilirubin metabolism, and water, electrolyte, and acid-base balance. Also discussed are the endocrine system, nervous system, and immunological mechanisms.

The excellent pattern of discussion makes it easier to understand these complex processes. Each chapter first presents the physiological processes required to adjust to intrauterine environment. Then the pathophysiological alterations that may occur are analyzed. Descriptions follow of the normal physiological changes happening immediately after clamping of the umbilical cord and initiation of breathing. Finally,