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April 25, 1977

Prenatal Diagnosis of Neural Tube Defects

JAMA. 1977;237(17):1824. doi:10.1001/jama.1977.03270440014002

To the Editor.—  I was surprised to read in the report by Macri et al (236:1251, 1976) that they were aware of no prospectively prenatally diagnosed cases of open neural tube defects. Their report details the prenatal diagnosis of two cases detected from their studies of 20 pregnancies at risk. They failed to mention our experience with the prenatal diagnosis of neural tube defects in 24 cases1 and, later, with 48 cases.2In contrast to the 20 pregnancies at risk that they have monitored by α-fetoprotein assay, we have now studied more than 1,000 such pregnancies against the background of a total experience exceeding 6,000 cases. Some of this experience has been reported recently.3,4