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April 25, 1977

Prevention of Hyaline Membrane Disease With Plasminogen: A Cooperative Study

Author Affiliations

From the Roswell Park Memorial Institute (Drs C. Ambrus, Bross, J. Ambrus, and Mr Jung); and the Departments of Pediatrics (Drs C. Ambrus, Choi, Cunnanan, Eisenberg, Staub, and Weintraub), Obstetrics-Gynecology (Drs Courey and Patterson), Pathology (Drs Jocken and Pickren), and Medicine (Dr J. Ambrus), State University of New York, Buffalo.

JAMA. 1977;237(17):1837-1841. doi:10.1001/jama.1977.03270440027015

In a double-blind, randomized study, 500 premature infants were treated with plasminogen or placebo intravenously within 60 minutes of birth. There was a substantial decrease in severe clinical respiratory distress, death caused by hyaline membrane disease, and total mortality in the plasminogen-treated infants as compared to the controls.

(JAMA 237:1837-1841, 1977)