In a double-blind, randomized study, 500 premature infants were treated with plasminogen or placebo intravenously within 60 minutes of birth. There was a substantial decrease in severe clinical respiratory distress, death caused by hyaline membrane disease, and total mortality in the plasminogen-treated infants as compared to the controls.
(JAMA 237:1837-1841, 1977)
Ambrus CM, Choi TS, Cunnanan E, et al. Prevention of Hyaline Membrane Disease With Plasminogen: A Cooperative Study. JAMA. 1977;237(17):1837–1841. doi:10.1001/jama.1977.03270440027015
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