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April 25, 1977

The Biochemistry and Physiology of Bone, vol 4: Calcification and Physiology

Author Affiliations

University of Iowa Hospitals and Clinics Iowa City

JAMA. 1977;237(17):1873-1874. doi:10.1001/jama.1977.03270440063033

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


The latest volume in this excellent series fulfills a stated desire of the editor to produce a relatively complete treatise on bone. Although not originally planned, volume 4 became an obvious necessity to cover several important topics omitted from preceding issues.

For the most part, the authors of each chapter write with a clarity that reflects their expertise and understanding of the subject. Superbly reproduced photographs and diagrams and an extensive bibliography greatly enhance each section.

The initial chapter summarizes the vast and rapidly accumulating data on mineralization and gives reason to believe that in the not-too-distant future, we may finally learn what makes a matrix mineralize. A lucid discussion of pyrophosphate and diphosphonates delineates their role in this puzzle in both health and disease. Their use in certain clinical syndromes has been promising. Perhaps one of the most intriguing narratives in recent months has been that of matrix vesicles.