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February 4, 1974

Iatrogenic Bleeding

JAMA. 1974;227(5):558. doi:10.1001/jama.1974.03230180056024

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To the Editor.—  We have recently seen a problem that we think should be called to the attention of practitioners throughout the country.A 24-year-old man, previously in good health, had been donating plasma at a local collecting center. It was noted that clotting at the venipuncture site failed to occur, even after considerable time. At the local emergency room, clotting studies revealed an activated partial thromboplastin time (APTT) of 71 seconds (normal, less than 45 seconds). The coagulation time was 71 minutes. Other clotting studies, including prothrombin time, platelets, and fibrinogen, gave normal results. Shortly afterwards, he ceased to have bleeding from the venipuncture site, but was kept in the hospital overnight. By the next morning, the APTT and coagulation time had reverted to normal. The patient was discharged and since has had no difficulty.The collecting agency told us that they had recently received a directive from their