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May 2, 1977

Diagnosis of Mycoplasma pneumoniae Infection-Reply

JAMA. 1977;237(18):1930. doi:10.1001/jama.1977.03270450019009

We acknowledge a misprint in our case report; the sentence should read "Streptococcus antibody was present (in the serum) in a dilution of 1:128."

The questions raised by Dr Lind can be easily dismissed by a look into the published literature on the subject. A high titer of CA usually indicates Mycoplasma pneumoniae infection.1-3 A fourfold rise in the titer of CA is a feature of Mycoplasma infection (191:369,1965).3-6 The titer of CA in infections other than Mycoplasma is usually low.4 The severity of illness from Mycoplasma pneumoniae infection was not correlated with CA titer (191:369, 1965). We did not postulate the mechanism of CA production in Mycoplasma pneumoniae infection; there are several articles in publication on this topic.4,7,8 Discrepancy of positive results between specific antibody titer by immunofluorescence and complement fixation test of Mycoplasma pneumoniae is a result of the inheritant nature of