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May 2, 1977

Aggravation of Diabetic Hyperglycemia by Chlordiazepoxide

Author Affiliations

From the Department of Oncology and the Clinical Research Center, Montefiore Hospital and Medical Center, Bronx, NY.

JAMA. 1977;237(18):1960-1961. doi:10.1001/jama.1977.03270450050019

The administration of chlordiazepoxide hydrochloride, 40 mg daily, aggravated the hyperglycemia in an insulin-dependent, maturity-onset diabetic woman, raising the fasting blood glucose values from 220 mg/100 ml to 380 mg/100 ml. Review of the literature shows that virtually all psychoactive drugs affect diabetes; most tranquilizers aggravate diabetic hyperglycemia, while most antidepressants ameliorate it. The effect described in this communication is of clinical importance because of the widespread use of the benzodiazepine tranquilizers.

(JAMA 237:1960-1961, 1977)