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February 11, 1974

Methadone Maintenance

Author Affiliations


JAMA. 1974;227(6):660. doi:10.1001/jama.1974.03230190052025

To the Editor.—  Detoxification from methadone maintenance therapy is the subject of a study and of separate editorial comment in the same issue of The Journal by the same author, Dr. Vincent Dole (226:747 and 780, 1973).The optimal dosage and duration of medication are important subjects medically, economically, and, as Dr. Dole suggests, politically.In his initial report in The Journal (193:646, 1965), Dr. Dole promised control studies "with social support but without medication."1 Not only has this not been accomplished by his group, but control studies of different dosages have not been reported by them.Berry has reported careful doubleblind studies2 of maintenance dosages of 100 and 50 mg daily, and found no significant differences in results. Also, results similar to Berry's have been found by Goldstein and co-workers.3 Yet, despite this documented evidence, Cushman and Dole state, "new patients, in our opinion, should be