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March 23, 1970

Joint Study of Extracranial Arterial Occlusion: V. Progress Report of Prognosis Following Surgery or Nonsurgical Treatment for Transient Cerebral Ischemic Attacks and Cervical Carotid Artery Lesions

Author Affiliations

From the University of Texas Graduate School of Biomedical Sciences, Houston (Dr. Fields and Miss Macdonald); the Instituto de Neurología, Hospital de Clinicas Montevideo, Uruguay (Dr. Maslenikov); Department of Neurology, Baylor College of Medicine, Houston (Dr. Meyer); Department of Neurology and Psychiatry, New York University School of Medicine, New York (Dr. Hass); and the University of Texas School of Public Health, Houston (Dr. Remington).

JAMA. 1970;211(12):1993-2003. doi:10.1001/jama.1970.03170120039008

A series of 316 patients with transient cerebral ischemic attacks and no neurological deficit were randomly allocated to surgical or nonsurgical treatment categories in a controlled manner. The total group was divided by anatomical patterns of lesions (carotid stenosis, unilaterally; carotid stenosis, bilaterally; and unilateral occlusion with opposite stenosis). During an average 42-month follow-up, distinct differences in outcome were noted in specific subgroups in the frequency and pattern of transient attacks and in the occurrence and location of cerebral infarction.