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March 23, 1970

Renin and Hypertension: A Modern Synthesis

Author Affiliations

Mt. Sinai Hospital Cleveland

JAMA. 1970;211(12):2019-2020. doi:10.1001/jama.1970.03170120063026

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Michael Lee has stated his purpose in the preface: to provide the general reader with an introduction to the subject of renin and its relation to blood pressure. He has succeeded admirably, with a clear, simple presentation abundantly documented. As befits an unsettled, growing topic, his tone is free from shrillness, dogmatism, and premature judgments. The book is well planned. The first section describes renin, its discovery, chemistry, and physiology. The section on renin measurement will not guide the reader through the confusing nomenclature, but Dr. Lee did not build this Tower of Babel. He would undoubtedly sign a petition to have it torn down.

The second section concerns itself with renin and blood pressure. The presentation is well conceived, beginning with the role of renin in experimental hypertension and proceeding to clinical observations. The final chapter, a brief one entitled "A Modern Synthesis," represents a direct effort to make