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February 25, 1974

Hepatitis B Infection: A Point-Prevalence Study in 15 US Hemodialysis Centers

Author Affiliations

From the National Collaborative Study of Hepatitis B Immune Globulin in Prevention of Dialysis-Associated Hepatitis. Dr. Szmuness is with the New York Blood Center and the Department of Epidemiology, Columbia University School of Public Health, New York; Dr. Prince is with the New York Blood Center and the Department of Pathology, New York Hospital-Cornell Medical Center; Dr. Grady is with the State Laboratory Institute, Massachusetts Department of Public Health, Boston; Ms. Mann and Mr. Levine are with The New York Blood Center; Dr. Friedman and Ms. Josephson are; with the Downstate University Medical Center, Brooklyn, NY; Dr. Jacobs is with Saint Barnabas Medical Center, Livingston, NJ; Dr. Ribot is with Beth Israel Medical Center, Newark, NJ; Dr. Shapiro is with Regional Kidney Disease Center, Minneapolis; Dr. Stenzel is with New York Hospital-Cornell Medical Center; Dr. Suki is with the Texas Medical Center, Baylor College of Medicine, Houston; and Dr. Vyas is with the Department of Clinical Pathology and Laboratory Medicine, University of California, San Francisco.

JAMA. 1974;227(8):901-906. doi:10.1001/jama.1974.03230210013003

Five hundred eighty-three patients and 451 medical personnel of 15 hemodialysis centers were surveyed for hepatitis B infections. Hepatitis B antigen (HB Ag) was detected in 16.8% of the patients and in 2.4% of the medical staff; specific antibody to HB Ag (HB Ab) was detected in 34.0% and 31.3%, respectively. The cumulative prevalence of HB Ag and HB Ab varied widely among the centers. The prevalence of HB Ag or HB Ab in patients was related to duration of dialysis treatment, but not to blood transfusions. Significant differences in prevalence of serologic indicators of hepatitis B infection among various staff categories were not observed. Sixty-one percent of family contacts of dialysis patients with a history of hepatitis B infection were found to have HB Ag or HB Ab.