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February 25, 1974

Familial Hyperlipoproteinemia

JAMA. 1974;227(8):935. doi:10.1001/jama.1974.03230210045012

Knowing that there are two types of hyperlipoproteinemia, Glueck et al1 sought to identify hyperlipoproteinemia of children in families in which one parent had suffered myocardial infarction before the age of 50 years. The authors reasoned that such relatively early onset of coronary artery disease might well indicate familial disease and portend early development of atheromatosis in progeny.

To accomplish their purpose, the authors enlisted the assistance of local physicians (mainly pediatricians) in a search for families suitable for investigation. By this means, 70 kindreds were identified in which one parent had suffered a morbid or lethal myocardial infarction before age 50. Blood lipid and lipoprotein values were measured in 57 of the 70 afflicted parents. (Thirteen parents had died before the study was undertaken.) Similar measurements were obtained in 223 of 224 living children of the affected parents as well as in first-degree relatives in an attempt to