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May 16, 1977

Does Disulfiram Cure Psoriasis?

Author Affiliations

Ridgewood, NJ

JAMA. 1977;237(20):2189. doi:10.1001/jama.1977.03270470025014

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To the Editor.—  In a recent issue of The Journal (236:2328, 1976), in the QUESTIONS AND ANSWERS section, a physician from North Carolina inquired if disulfiram cures psoriasis.I would like to express the opinion I have held for a number of years: that alcoholic beverages have an extraordinarily deleterious effect on patients with psoriasis and worsen the extent and severity of their disease. I feel that hospitalization of patients with psoriasis is so much more effective in their treatment, even though that treatment might be ostensibly identical to the treatment they were receiving as outpatients, because, while hospitalized, they are deprived of an ordinary, if not extraordinary, intake of alcohol. Therefore, I do not think that disulfiram has a pharmacologic effect on psoriasis in a direct manner, but it does have a beneficial effect indirectly by interdicting the use of alcohol.

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