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May 16, 1977

Injection Mammography

JAMA. 1977;237(20):2219-2220. doi:10.1001/jama.1977.03270470055027

WITH THE advent of mammography and xeromammography, the occult nonpalpable lesion has created a new problem for both the surgeon and pathologist. A small lesion is usually difficult and sometimes impossible for the surgeon to locate at the time of biopsy and, therefore, frequently necessitates a large deforming biopsy to ensure removal of the lesion. If the lesion is benign, the patient is left with a permanent breast deformity.

Several techniques have been advocated to assist in localizing the nonpalpable lesions.1-4 The injection of a mixture of Evans blue dye or indocyanine green and radiopaque contrast material has proved to be a successful method in our series. A protocol (Fig 1) is recommended in the radiographic assessment of nonpalpable lesions of the breast.

Method  Several hours prior to surgery, two parts of a mixture of meglumine and sodium salts of diatrizoate (Renografin 60) was combined with one part of