Dietary treatment was minimally effective in two children with homozygous type II hyperlipoproteinemia who had no evidence of atherosclerosis. Neither patient could tolerate cholestyramine resin in therapeutic doses. A partial ileal bypass operation was performed on each child, aged 10 and 8 years old. Although plasma cholesterol levels were not reduced to accepted normal values, they were reduced by 42% and 33%, respectively, below the average preoperative postdietary levels. Three years after the operations, neither child shows adverse effects on health and growth, and there is still no evidence of atherosclerosis.
Balfour JF, Kim R. Homozygous Type II Hyperlipoproteinemia Treatment: Partial Ileal Bypass in Two Children. JAMA. 1974;227(10):1145–1151. doi:10.1001/jama.1974.03230230021014
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