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March 11, 1974

Homozygous Type II Hyperlipoproteinemia Treatment: Partial Ileal Bypass in Two Children

Author Affiliations

From the departments of surgery (Dr. Balfour) and dermatology (Dr. Kim), Straub Clinic and Hospital, Inc, Honolulu.

JAMA. 1974;227(10):1145-1151. doi:10.1001/jama.1974.03230230021014

Dietary treatment was minimally effective in two children with homozygous type II hyperlipoproteinemia who had no evidence of atherosclerosis. Neither patient could tolerate cholestyramine resin in therapeutic doses. A partial ileal bypass operation was performed on each child, aged 10 and 8 years old. Although plasma cholesterol levels were not reduced to accepted normal values, they were reduced by 42% and 33%, respectively, below the average preoperative postdietary levels. Three years after the operations, neither child shows adverse effects on health and growth, and there is still no evidence of atherosclerosis.