To determine whether bacteria present in ambient air play a role in the contamination of fine-particle reservoir nebulizers, nebulizers were placed in operation in separate hospital locations having qualitatively and quantitatively different bacterial flora in background air. Nebulizers placed in a surgical intensive care unit that had higher numbers of bacteria and a predominance of Gram-negative organisms in background air had a significantly higher incidence of nebulizer contamination (33.0%) than did nebulizers placed in a non-patient-care area that had lower bacterial counts and a predominance of Gram-positive organisms (0%) (P <.05). The present study indicates that airborne contamination of fine-particle reservoir nebulizers occurs when bacteria present in ambient air enter the nebulizer during its operation.
(JAMA 237:2311-2314, 1977)
Kelsen SG, McGuckin M, Kelsen DP, Cherniack NS. Airborne Contamination of Fine-Particle Nebulizers. JAMA. 1977;237(21):2311–2314. doi:10.1001/jama.1977.03270480051019
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