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March 18, 1974

Medical News

JAMA. 1974;227(11):1243-1255. doi:10.1001/jama.1974.03230240001001

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Six years and 12,000 men: some answers to heart disease  ?Can an "active intervention" program persuade middle-aged men to reduce their serum cholesterol, blood pressure, and cigarette smoking—and thus reduce their death rate from coronary heart disease?This is the basic question to be answered by a massive, long-term study getting underway at 20 clinical centers in the United States. The six-year study is sponsored by the National Heart and Lung Institute.Approximately 12,000 volunteer men are being recruited. All will be apparently healthy, and between the ages of 35 and 57—but all will have one or more of the risk factors, that is, elevated serum cholesterol, hypertension, or the habit of smoking cigarettes.Half the men will be randomly assigned to "intervention programs" designed to persuade them to do such things as change their diets and stop or cut down on their smoking. The rest will be referred to