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March 18, 1974

Normal Chromosome Findings In Spray-Adhesive Users

Author Affiliations

School of Medicine University of Washington Seattle

JAMA. 1974;227(11):1259-1260. doi:10.1001/jama.1974.03230240017007

To the Editor.—  Spray adhesive products have recently been banned by the US Consumer Product Safety Commission, and the public was warned about possible genetic damage therefrom. This was based on unpublished data from J. Rodman Seely (University of Oklahoma), showing an increased frequency of chromosomal gaps and breaks in lymphocytes cultured from two unrelated dysmorphic infants and their spray-adhesive user parents, plus four other adults who were spray-adhesive users. Chromosomal gaps plus breaks in the aforementioned group of ten individuals averaged 9% vs 1.65% in the control group.Herein, we report the findings in six adult spray-adhesive users and the infant offspring of one. These individuals were referred for study because of the public warning of possible genetic or teratogenic effects, a warning we consider to have been premature. None of the individuals had experienced clinical symptoms related to their use of spray adhesives.Subject 1, who was in