IT HAS been reported recently that patients with meningococcal disease and meningococcal capsular antigens detectable in the serum had more severe disseminated intravascular coagulation (DIC), and a generally worse prognosis than patients without detectable antigenemia.1 Counterimmunoelectrophoresis (CIE) is a rapid and simple method for detecting pneumococcal, meningococcal, and Haemophilus antigens in patients' sera and other body fluids.2,3 We describe a patient with fulminant meningococcemia and severe DIC who had a high level of meningococcal antigen in the serum as detected by CIE.
Report of a Case
A 17-year-old girl was admitted on Aug 16, 1973, because of shaking chills, fever, headache, confusion, and the development of a diffuse rash within the 12 hours preceding her admission to the hospital. On examination, she appeared acutely ill, cyanotic and restless. Blood pressure was 60/40 mm Hg; respirations, 30/min; pulse, 120 beats per minute (regular, but thready); and temperature was 37.5
Ferstenfeld JE, Rytel MW. Fulminant Meningococcemia With High Serum Level of Meningococcal Capsular Antigen. JAMA. 1974;227(11):1301–1302. doi:10.1001/jama.1974.03230240059028
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