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April 6, 1970

Malaria Chemoprophylaxis In Vietnam and Post-Vietnam

Author Affiliations

USA II Field Force Vietnam

JAMA. 1970;212(1):159. doi:10.1001/jama.1970.03170140115032

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To the Editor.—  While stationed in Vietnam, US servicemen take a pill once a week which contains chloroquine phosphate, 500 mg (equivalent to 300 mg of the base), and primaquine phosphate, 79 mg (equivalent to 45 mg of the base).The combination of chloroquine and primaquine has proved much more effective—100% effective in servicemen who take the pill regularly—than chloroquine alone for the prevention of malaria due to Plasmodium vivax. However, it has no prophylactic value for malaria due to P falciparum in Southeast Asia. Therefore, those servicemen stationed in an area where falciparum malaria is endemic take a daily dose of dapsone, 25 mg, in addition to the chloroquine-primaquine pill.Upon return to the United States, servicemen are instructed to take one chloroquine-primaquine pill weekly, for eight weeks following departure from Vietnam. In addition, those servicemen who have been stationed in an area where falciparum malaria is endemic are