Neisseria gonorrhoeae resistant to high levels of spectinomycin (more than 2,048 μg/ml), were isolated from specimens obtained from a patient with urethritis. The bacterial resistance to spectinomycin is probably due to ribosomal changes that are a result of a chromosomal mutation. If spectinomycin fails to cure gonorrhea, spectinomycin resistance should be considered.
(JAMA 237:2405-2406, 1977)
Thornsberry C, Jaffee H, Brown ST, Edwards T, Biddle JW, Thompson SE. Spectinomycin-Resistant Neisseria gonorrhoeae. JAMA. 1977;237(22):2405–2406. doi:10.1001/jama.1977.03270490045024
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