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May 30, 1977

Treating Acute Acetaminophen Poisoning With Acetylcysteine

Author Affiliations

From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Medical Center; and the Rocky Mountain Poison Center, Denver General Hospital, Denver.

JAMA. 1977;237(22):2406-2407. doi:10.1001/jama.1977.03270490046025

A patient ingested 15.6 gm acetaminophen and sought medical attention after seven hours. At that time, her plasma acetaminophen level was 217μg/ml. Treatment with acetylcysteine was begun eight hours after the ingestion. The clinical course of this patient was characterized by a mild illness with a minor elevation of liver enzyme values. A number of factors predicted severe hepatotoxicity for this patient had she not received treatment.

(JAMA 237:2406-2407, 1977)