The possible influence of oral contraceptives on the development of functional ovarian cysts requiring surgical removal was explored in a survey of 24 hospitals. Of 60 women aged 20 to 44 years who had functional cysts, 1.7% used oral contraceptives, while 20% of 842 controls used these drugs (P<.002). By contrast, 20% of 70 women with nonfunctional cysts used oral contraceptives. Among women aged 20 to 44 years, the estimated deficit in the rate of hospital admissions for surgical removal of functional ovarian cysts that can be attributed to oral contraceptives is about 35/100,000 yearly.
(JAMA 228:68-69, 1974)
Functional Ovarian Cysts and Oral Contraceptives: Negative Association Confirmed Surgically. JAMA. 1974;228(1):68–69. doi:10.1001/jama.1974.03230260042022
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